publications | card-ii-omics

Publications & press

Publications

2020

T. C. Meyer, F. Schmidt, J. Steinke, B. M. Bröker, U. Völker, S. Michalik. xMAPr – high-dynamic-range (HDR) quantification of antigen specific antibody binding. J Proteomics. 2020 Feb 10;212:103577

2019

M. Sombetzki, A. Rabes, M. Bischofsberger, F. Winkelmann, N. Koslowski, C. Schulz, E. C. Reisinger. Preventive CTLA-4-Ig treatment reduces hepatic fibrosis and egg load in Schistosoma mansoni infected mice. BioMed Research International. 2019 Dec 16;2019:1704238.

S. Blankenburg, C. Hentschker, A. Nagel, P. Hildebrandt, S. Michalik, D. Dittmar, K. Surmann, U. Völker. Improving proteome coverage for small sample amounts: an advanced method for proteomics approaches with low bacterial cell numbers. Proteomics. 2019. Dec;19(23):e1900192

S. Illner, D. Arbeiter, M. Teske, V. Khaimov, S. Oschatz, V. Senz, K.-P. Schmitz, N. Grabow, S. Kohse. Tissue biomimicryTissue biomimicry using cross-linked electro-spun nonwoven fibre composites. Current Directions in Biomedical Engineering. 2019;5(1):119-122

M. Stiehm, F. Borowski, S. Kaule, R. Ott, S. Pfensig, S. Siewert, N. Grabow, A. Öner, K.-P. Schmitz. Computational flow analysis of the washout of an aortic valve by means ofEulerian transport equation. Current Directions in Biomedical Engineering. 2019;5(1):123-126

T. Eickner, S. Kohse, S. Illner, S. Oschatz, M. Teske, N. Rekowska, V. Senz, K.-P. Schmitz, N. Grabow. Formation and characterisation of hydrogel diffusion channels for directed drug delivery. Current Directions in Biomedical Engineering. 2019;5(1):323-326

F. Borowski, J. Oldenburg, S. Kaule, S. Großmann, S. Siewert, N. Grabow, A. Öner, K.-P. Schmitz, M. Stiehm. Investigation of the hemodynamic properties of transcatheter aortic valve prostheses depending on degrees of degradation of the aortic valve leaflets. GALA German Association of Laser Anemometry. 2019.

E. C. Reisinger, M. Ebbers, M. Löbermann. Clostridium Difficile: Monoclonal Antibody Therapy and Vaccines. Dtsch Med Wochenschr. 2019;144(12):842-849

D. Raafat, M. Otto, K. Reppschläger, J. Iqbal, S. Holtfreter. Fighting Staphylococcus aureus biofilms with monoclonal antibodies. Trends in Microbiology. 2019. 27(4):303-322

2018

S. Kohse, D. Arbeiter, T. Reske, T. Eickner, M. Stiehm, K.-P. Schmitz, N. Grabow. Electrospinning for polymeric implants in cardiovascular applications. Current Directions in Biomedical Engineering. 2018; 4(1):89-92

D. Arbeiter, S. Kohse, T. Eickner, K.-P. Schmitz, N. Grabow. Influence of additives on physico-chemical properties of electrospun poly(L-lactide). Current Directions in Biomedical Engineering. 2018; 4(1):493-496

K. Wulf, D. Arbeiter, T. Eickner, K. Riedel, K.-P. Schmitz, N. Grabow, S. Kohse. Polymer drug release system for biofilm inhibition in medical application. Current Directions in Biomedical Engineering. 2018; 4(1):213-216

F. Borowski, M. Sämann, S. Pfensig, C. Wüstenhagen, R. Ott, S. Kaule, S. Siewert, N. Grabow, K.-P. Schmitz, M. Stiehm. Fluid-structure interaction of heart valve dynamics in comparison to finite-element analysis. Current Directions in Biomedical Engineering. 2018; 4(1):259-262

M. Stiehm, F. Borowski, R. Ott, S. Kaule, C. Wüstenhagen, S. Pfensig, S. Siewert, N. Grabow, K.-P. Schmitz. Hämodynamische Analyse der Aortenklappe mittels Fluid-Struktur Interaktion. Fachtagung: Experimentelle Strömungsmechanik. 2018; 37.1-37.8 (ISBN 978-3-9816764-5-7)

M. Nordengrün, S. Michalik, U. Völker, B. M. Bröker, L. Gómez-Gascón. The quest for bacterial allergens. International Journal of Medical Microbiology. 2018. 308(6):738-750.

N. M. Darisipudi, M. Nordengrün, B. M. Bröker, V. Péton. Messing with the Sentinels-The Interaction of Staphylococcus aureus with Dendritic Cells. Microorganisms. 2018; 15;6(3)

M. Sombetzki, N. Koslowski, A. Rabes, S. Seneberg, F. Winkelmann, C. Fritzsche, M. Loebermann, E. C. Reisinger. Host Defense Versus Immunosuppression: Unisexual Infection With Male or Female Schistosoma mansoni Differentially Impacts the Immune Response Against Invading Cercariae. Front Immunol. 2018; 9:861

Presentations

2019

S. Illner, D. Arbeiter, M. Teske, V. Khaimov, S. Oschatz, V. Senz, K.-P. Schmitz, N. Grabow, S. Kohse. Tissue biomimicry using cross-linked electro-spun nonwoven fibre composites. Three-Country Conference. Joint Annual Conference of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering. 09/2019, Frankfurt.

M. Stiehm, F. Borowski, S. Kaule, R. Ott, S. Pfensig, S. Siewert, N. Grabow, A. Öner, K.-P. Schmitz. Computational and experimental flow analysis of the thrombotic potential of transcatheter aortic valve prostheses according to ISO 5840. Three-Country Conference. Joint Annual Conference of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering. 09/2019, Frankfurt.

J. Oldenburg, F. Borowski, A. Öner, L. Quirin, K. John, M. Bruschewski, S. Grundmann, K.-P. Schmitz, M. Stiehm. MRV-validated numerical flow analysis of thrombotic potential of coronary stent designs. Three-Country Conference. Joint Annual Conference of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering. 09/2019, Frankfurt.

N. Grabow, V. Senz, K.-P. Schmitz. Medical device innovations for cardiovascular, ophthalmologic and otolaryngologic applications. Three-Country Conference. Joint Annual Conference of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering. 09/2019, Frankfurt.

F. Borowski, J. Oldenburg, S. Kaule, S. Großmann, S. Siewert, N. Grabow, A. Öner, K.-P. Schmitz, M. Stiehm. Untersuchung der hämodynamischen Eigenschaften von Transkatheter-Aortenklappenprothesen in Abhängigkeit des Degradationsgrades der Klappentaschen. GALA Symposium "Experimental Fluid Mechanics”. 09/2019, Erlangen.

B. M. Bröker. Plenary lecture: The immune system beyond sepsis – B cells and regulatory T cells. Sepsis Update 2019. 09/2019, Weimar.

N. Grabow. Translation innovativer Medizinprodukte aus der Wissenschaft in die Wirtschaft und in die Klinik. 15. Nationale Branchenkonferenz Gesundheitswirtschaft. 06/2019, Warnemünde.

B. M. Bröker. Plenarvortrag: Immune control of Staphylococcus aureus in the post genomic era. eCells & Materials – XIX Orthopaedic Infection Meeting. 06/2019, Davos, Schweiz.

M. Sombetzki, A. Rabes, M. Bischofsberger, F. Winkelmann, C. Schulz, E. C. Reisinger. Keynote lecture: Host defense versus immunosuppression: Male and female Schistosoma mansoni differentially impact the host's immune system. 25th Helminthological Days. 05/2019. Rejčkov. Czech Republic.

A. Rabes, M. Bischofsberger, F. Winkelmann, C. Schulz, E. C. Reisinger, M. Sombetzki. CTLA4-Ig – a potential drug for the treatment of hepatic fibrosis in Schistosomiasis? 25th Helminthological Days. 05/2019. Rejčkov. Czech Republic.

N. Grabow. Entwicklung neuer Implantatkonzepte für das Herz-Kreislauf-System, Auge und Ohr. Biosystem-Material-Interaktion. 04/2019. Rostock.

V. Pauker, D. Gottschling, L. Maletzki, A. Strohbach, S. Petersen, S. Kohse, N. Grabow, K. Riedel. In vitro evaluation of biofilm-inhibiting compounds to treat infective endocarditis. Jahrestagung der Vereinigung Allgemeiner und Angewandter Mikrobiologie. 03/2019. Mainz.

M. Sombetzki, F. Winkelmann, A. Rabes, N. Koslowski, M. Bischofsberger, M. Trauner, E. C. Reisinger. When non-specific beats specific treatment: Behind the scene of T-cell mediated hepatic fibrosis in Schistosoma mansoni infection. Joint meeting of the 20th Anniversary Drug Design & Development Seminar of the German Society for Parasitology & the LOEWE Center DRUID. 03/2019. Giessen.

N. Normann, J. Beitz, M. Gründling, A. Kühn, C. Fuchs, J. Kolata, T. Meyer, S. Michalik, K. Schulz, I. Steinmetz, M. Nauck, K. Meissner, U. Völker, B. M. Bröker, S. Holtfreter, D. Raafat. Infection array - Using antibody signatures for developing an immunological tool to complement pathogen-targeted diagnostics. Annual Meeting of the Working Groups for Infection Immunology of the DGfI and DGHM. 03/2019, Burg Rothenfels.

B. M. Bröker. Plenary lecture: The quest for staphylococcal allergens. Deutsche Gesellschaft für Allergologie und Klinische Immunologie, 03/2019, Mainz.

N. Grabow. Entwicklung neuer Implantatkonzepte für das Herz-Kreislauf-System, Auge und Ohr. Kunststoff trifft Medizintechnik, 01/2019, Leipzig.

2018

S. Kohse, K. Wulf, V. Pauker, D. Arbeiter, N. Fiedler, D. Bajer, T. Eickner, K. Riedel, K.-P. Schmitz, N. Grabow. Local drug delivery from transcatheter heart valves for the prevention of implant infection - chitosan as adhesion promoter for polymer/drug coating. Jahrestagung der Deutschen Gesellschaft für Biomaterialien. 11/2018, Braunschweig.

F. Borowski, M. Sämann, S. Pfensig, C. Wüstenhagen, R. Ott, S. Kaule, S. Siewert, N. Grabow, K.-P. Schmitz, M. Stiehm. Fluid-structure interaction of heart valve dynamics in comparison to finite-element analysis. 52nd Annual Conference of the German Society for Biomedical Engineering. 11/2018, Aachen. *Awarded 6th place in the VDE student competition*

E. C. Reisinger. Immunotherapie und Impfungen bei Bakteriellen Erkrankungen. 26th Annual Meeting of the Paul Ehrlich Society. 10/2018, Wien, Austria.

B. M. Bröker. Plenarvortrag: in airway disease: allergen – superantigen – superallergen? 12th International Symposium on Experimental Rhinology and Immunology of the Nose (SERIN). 10/2018, Gent, Belgium.

K. Wulf, D. Arbeiter, T. Eickner, K. Riedel, K.-P. Schmitz, N. Grabow, S. Kohse. Polymer drug release system for biofilm inhibition in medical application. 52nd Annual Conference of the German Society for Biomedical Engineering. 09/2018, Aachen.

S. Kohse, D. Arbeiter, T. Reske, T. Eickner, M. Stiehm, K.-P. Schmitz, N. Grabow. Electrospinning for polymeric implants in cardiovascular applications. 52nd Annual Conference of the German Society for Biomedical Engineering. 09/2018, Aachen.

M. Nordengrün, A. Teufelberger, S. Michalik, S. Stentzel, F. Schmidt, O. Krysko, N. M. Darisipudi, U. Völker, C.Bachert, B. M. Bröker. S. aureus serine proteases are inducers of airway allergies. 2nd International Symposium - Allergy meets Infection, 09/2018, Lübeck.

M. Stiehm, F. Borowski, R. Ott, S. Kaule, C. Wüstenhagen, S. Pfensig, S. Siewert, N. Grabow, K.-P. Schmitz. Hämodynamische Analyse der Aortenklappe mittels Fluid-Struktur Interaktion. Symposium: Experimental Fluid Mechanics. 09/2018, Rostock.

H. Ince, A. Öner, W. Schmidt, K.-P. Schmitz, N. Grabow. Expert Panel Discussion. German Cardiology Night. 09/2018, San Diego, California, USA.

B. M. Bröker. Multifaceted interaction with the adaptive immune system. International Symposium on Staphylococci and Staphylococcal Diseases. 08/2018, Kopenhagen, Denmark.

B. M. Bröker. Keynote lecture: Bacteria and the airways: A magic triangle of tolerance, defense and sensitization. Congress of the European Association of Allergy and Clinical Immunology. 05/2018, München.

E. C. Reisinger. Card-ii-Omics: Kardiovaskuläre Implantatentwicklung - Herzklappeninfektionen - Proteomics. 14th National Industry Conference Health Care Industry. 05/2018. Warnemünde.

B. M. Bröker. Keynote lecture: Bacteria and the airways: A magic triangle of tolerance, defense and sensitization. Kongress der European Association of Allergy and Clinical Immunology (EAACI). 05/2018, München.

Posters

2019

N. Normann, M. Gründling, S. Michalik, T. C. Meyer, G. Abdurrahman, U. Völker, B. M. Bröker, S. Holtfreter, D. Raafat. Screening antibody signatures against major bacterial pathogens using the “Infection Array”, a high-throughput assay based on the xMAP® technology. xMAP Connect Amsterdam. 11/2019. Amsterdam, Niederlande.

D. Arbeiter, S. Oschatz, S. Illner, N. Grabow. The effect of diamine treatment on the physico-chemical properties of polyimide electrospun nonwovens. Dreiländertagung D-A-CH. Joint Annual Conference of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering. 09/2019. Frankfurt.

J. Iqbal, S. Michalik, C. Hentschker, K. Surmann, M. Gesell Salazar, L. Busch, T. Meyer, E. Ruotsalainen, V. P. Kontinen, B. M. Bröker, U. Völker, S. Holtfreter. Proteomics and immunoproteomics provide insights into bacterial and host factors contributing to the outcome of Staphylococcus aureus infective endocarditis. II Joint Meeting of the German Society for Immunology (DGfl) and the Italian Society of Immunology, Clinical Immunology and Allergology (SIICA). 09/2019. München.

F. Winkelmann, A. Rabes, M. Bischofsberger, M. Frank, E. C. Reisinger, M. Sombetzki. Human serum differentially impacts membrane turnover of male and female Schistosoma mansoni. Joint meeting of the 20th Anniversary Drug Design & Development Seminar of the German Society for Parasitology & the LOEWE Center DRUID. 03/2019. Giessen.

A. Rabes, M. Bischofsberger, F. Winkelmann, E. C. Reisinger, M. Sombetzki. CTLA4-Ig - a potential drug for the treatment of hepatic fibrosis in schistosomiasis? Joint meeting of the 20th Anniversary Drug Design & Development Seminar of the German Society for Parasitology & the LOEWE Center DRUID. 03/2019. Giessen.

C. Hentschker, K. Surmann, S. Michalik, L. Busch, J. Iqbal, M. Gesell Salazar, T. Meyer, E. Ruotsalainen, V. P. Kontinen, S. Fuchs, U. Mäder, B.M. Bröker, S. Holtfreter, U. Völker. Proteomics and immunoproteomics characterization of Staphylococcus aureus strains causing infective endocarditis. Proteomic Forum. XIII. Annual Congress of the European Proteomics Association. 03/2019, Potsdam.

2018

F. Borowski, M. Stiehm, S. Kohse. Heart valve prosthesis – structural and fluid mechanical methods to reduce the risk of infection. Forschungscamp der Universität Rostock. 11/2018, Rostock.

V. Pauker, D. Gottschling, L. Maletzki, A. Strohbach, S. Kohse, S. Petersen, N. Grabow, K. Riedel. In vitro evaluation of biofilm-inhibiting compounds to treat infective endocarditis. Jahrestagung der Deutschen Gesellschaft für Biomaterialien. 11/2018, Braunschweig.

S. Michalik, T. C. Meyer, F. Schmidt, U. Völker. xMAPr – an app to analyze, visualize and inspect dilution-based serological assays using the xMAP® technology, xMAP® connect 2018. 11/2018, Amsterdam. *Awarded Poster Prize*

J. Iqbal, S. Michalik, C. Hentschker, K. Surmann, M. Gesell Salazar, P. Hildebrandt, J.-N. Tomzeck, L. Busch, T. Meyer, E. Ruotsalainen, V. P. Kontinen, B. M. Bröker, U. Völker, S. Holtfreter. Proteomics and immunoproteomics provide insights into bacterial and host factors contributing to the outcome of Staphylococcus aureus infective endocarditis. Autumn School of Immunology. 10/2018. Merseburg.

M. Sombetzki, N. Koslowski, A. Rabes, F. Winkelmann, C. Fritzsche, M. Löbermann, M. Trauner, E. C. Reisinger. Host defense versus immunosuppression: Male and female Schistosoma mansoni differentially impact the immune system. 26th Annual Meeting of the Paul Ehrlich Society. 10/2018, Wien.

M. Nordengrün, A. Teufelberger, S. Michalik, N. M. Darisipudi, O. Krysko, U. Völker, C. Bachert, B. M. Bröker. Staphylococcus aureus serine proteases are inducers of airway allergies. 2nd International Symposium - Allergy meets Infection. 09/2018, Lübeck. *Awarded Poster Prize*

D. Arbeiter, S. Kohse, T. Eickner, K.-P. Schmitz, N. Grabow. Influence of additives on physico-chemical properties of electrospun poly(L-lactide). 52nd Annual Conference of the German Society for Biomedical Engineering. 09/2018, Aachen.

S. Illner, S. Kohse, C. Michaelis, T. Reske, T. Eickner, K.-P. Schmitz, N. Grabow. In vitro study of sirolimus release from nonwoven PLLA matrices. 52nd Annual Conference of the German Society for Biomedical Engineering. 09/2018, Aachen.

M. Sombetzki, N. Koslowski, M. Loebermann, R. Engelmann, C. H. Österreicher, M. Trauner, B. Mueller-Hilke, E. C. Reisinger. Single-sex infection with female Schistosoma mansoni cercariae mitigates hepatic fibrosis after secondary infection. Parasitic Helminths - New Perspectives in Biology and Infection. 09/2018, Hydra. *Awarded Poster Prize*

P. Trübe, D. M. Mrochen, D. Schulz, S. Fischer, K. Jeske, T. Hertlein, D. Grumann, I. Jorde, K. Pritchett-Corning, S. Wiles, B. M. Bröker, R. G. Ulrich, K. Ohlsen, S. Holtfreter. Bringing together what belongs together: optimizing murine infection models by using mouse-adapted S. aureus strains. 18th International Symposium on Staphylococci and Staphylococcal Infections. 08/2018, Kopenhagen, Denmark.

J. Fischer, H. Bahl, K. Kriebel. Surface coating with D-amino acids impairs biofilm formation of Clostridium difficile. Annual Conference 2019 of the Association for General and Applied Microbiology. 03/2018, Mainz.

2017

S. Kohse, K. Wulf, D. Bajer, N. Grabow, K.-P. Schmitz, T. Eickner. Biofunctionalization of polymeric implant material – impact of nanofibrous structure. Annual Meeting of the German Society for Biomaterials. 11/2017, Würzburg.

K. Reppschläger, H.-P. Müller, S. Holtfreter, B. M. Bröker, D. Raafat. Detection of low frequency B cells specific for immunodominant virulence factors of Staphyolococcus aureus. 1st International Conference on Respiratory Pathogens. 11/2017, Rostock

K. Reppschläger, H.-P. Müller, B. M. Bröker, D. Raafat. A needle in a haystack? On the search for rare B cells specific for conserved immunogenic Staphylococcus aureus proteins.19th Germinal Centre Conference. 09/2017. Venedig.